Rabbit Anti-Human RAD51 (internal) Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human; Mouse

Immunogen

Synthetic peptide corresponding to a region derived from internal residues of human RAD51 homolog (S. cerevisiae)

Conjugate

Application Notes

IHC: 1:25-1:100

General Notes

This product (Catalog No. DPABH-00342) is a rabbit-derived IgG polyclonal antibody raised against human RAD51. This antibody exhibits cross-reactivity with RAD51 from mouse. It has been affinity purified by protein A. The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene.
DPABH-00342 is suitable for use in IHC (1:25–1:100) application.
DPABH-00342 is supplied as a liquid formulation in pH7.4 PBS, 0.05% sodium azide, 40% Glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

RECA; BRCC5; MRMV2; HRAD51; RAD51A; HsRad51; HsT16930

Entrez Gene ID

UniProt ID