Anti-RPTOR (middle region) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

a 15 amino acid peptide from the central region of human Raptor.

Conjugate

Alternative Names

RPTOR; regulatory associated protein of MTOR, complex 1; KOG1; Mip1; regulatory-associated protein of mTOR; raptor; p150 target of rapamycin (TOR)-scaffold protein containing WD-repeats

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Pathway

AMPK signaling; AMPK signaling pathway; Cellular response to heat stress; Cellular responses to stress; Energy dependent regulation of mTOR by LKB1-AMPK; HSF1-dependent transactivation; IGF1R signaling cascade; IRS-mediated signalling