Anti-RPS6KA3 monoclonal antibody, clone 467DU20.7.2.3

Antibody Isotype

IgG1

Clone

467DU20.7.2.3

Species Reactivity

Human; Mouse

Conjugate

Application Notes

WB: 1:500-16000

Alternative Names

RPS6KA3; ISPK1; MAPKAPK1B; RSK2; Ribosomal protein S6 kinase alpha-3; 90 kDa ribosomal protein S6 kinase 3; Insulin-stimulated protein kinase 1; MAP kinase-activated protein kinase 1b; Ribosomal S6 kinase 2; pp90RSK2

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a member of the RSK (ribosomal S6kinase) family of serine/threonine kinases. This kinase contains 2non-identical kinase catalytic domains and phosphorylates varioussubstrates, including members of the mitogen-activated kinase(MAPK) signalling pathway. The activity of this protein has beenimplicated in controlling cell growth and differentiation.Mutations in this gene have been associated with Coffin-Lowrysyndrome (CLS).

Pathway

Activated TLR4 signalling; Activation of NMDA receptor upon glutamate binding and postsynaptic events; Axon guidance; BDNF signaling pathway; CREB phosphorylation; CREB phosphorylation through the activation of Ras; Cellular Senescence; Cellular responses to stress;