Anti-RPS15 monoclonal antibody (CAB-4524MH)

Mouse anti-RPS15 monoclonal antibody for ELISA, WB, IF, IHC Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2b
Clone
MAAG1971
Species Reactivity
Human
Immunogen
RPS15 (NP_001009, 77 a.a. ~ 146 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Applications


Application Notes
WB: 1:500-1000
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
RPS15; ribosomal protein S15; 40S ribosomal protein S15; homolog of rat insulinoma; insulinoma protein; MGC111130
Entrez Gene ID
UniProt ID

Product Background


Gene summary
RPS15 (Ribosomal Protein S15) is a Protein Coding gene. Diseases associated with RPS15 include chronic lymphocytic leukemia and insulinoma. Among its related pathways are Gene Expression and Metabolism. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome. Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19P family of ribosomal proteins. It is located in the cytoplasm. This gene has been found to be activated in various tumors, such as insulinomas, esophageal cancers, and colon cancers. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants.
Antigen Description
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19P family of ribosomal proteins. It is located in the cytoplasm. This gene has been found to be activated in various tumors, such as insulinomas, esophageal cancers, and colon cancers. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Protein Symbol:P62841-RS15_HUMANRecommended name:40S ribosomal protein S15Protein Accession:P62841Secondary Accessions:A5D8V9P11174Q3KRA1Q9UDC240S ribosomal protein S15 is a protein that in humans is encoded by the RPS15 gene. 0The function about RPS15 antigen include DNA binding; RNA binding; structural constituent of ribosome.
Pathway
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, organism-specific biosystem; Cap-dependent Translation Initiation, organism-specific biosystem; Cytoplasmic Ribosomal Proteins, organism-specific biosystem; Disease, organism-specific biosystem; Eukaryotic Translation Elongation, organism-specific biosystem; Eukaryotic Translation Initiation, organism-specific biosystem; Eukaryotic Translation Termination, organism-specific biosystem.

Citations


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References


Gesser, B; Rasmussen, MK; et al. Dimethylfumarate inhibits MIF-induced proliferation of keratinocytes by inhibiting MSK1 and RSK1 activation and by inducing nuclear p-c-Jun (S63) and p-p53 (S15) expression. INFLAMMATION RESEARCH 60:643-653(2011).
KITAGAWA, M; TAKASAWA, S; et al. RIG ENCODES RIBOSOMAL PROTEIN-S15 - THE PRIMARY STRUCTURE OF MAMMALIAN RIBOSOMAL PROTEIN-S15. FEBS LETTERS 283:210-214(1991).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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