Anti-RNF213 (aa 2016-2112) polyclonal antibody

Species Reactivity

Human

Immunogen

C17orf27 (NP_065965, 2016 a.a. ~ 2112 a.a) partial recombinant protein with GST tag. The sequence is LSPENAKLLSTFLNQTGLDAFLLELHEMIILKLKNPQTQTEERFRPQWSLRDTLVSYMQT KESEILPEMASQFPEEILLASCVSVWKTAAVLKWNRE

Conjugate

Alternative Names

RNF213; ring finger protein 213; ALO17; MYMY2; MYSTR; NET57; C17orf27; KIAA1618; E3 ubiquitin-protein ligase RNF213; mysterin; ALK lymphoma oligomerization partner on chromosome 17;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a protein containing a C3HC4-type RING finger domain, which is a specialized type of Zn-finger that binds two atoms of zinc and is thought to be involved in mediating protein-protein interactions. The protein also contains an AAA domain, which is associated with ATPase activity. This gene is a susceptibility gene for Moyamoya disease, a vascular disorder of intracranial arteries. This gene is also a translocation partner in anaplastic large cell lymphoma and inflammatory myofibroblastic tumor cases, where a t(2;17)(p23;q25) translocation has been identified with the anaplastic lymphoma kinase (ALK) gene on chromosome 2, and a t(8;17)(q24;q25) translocation has been identified with the MYC gene on chromosome 8. Alternative splicing results in multiple transcript variants.