Anti-RNF19A (aa 739-837) polyclonal antibody

Species Reactivity

Human

Immunogen

RNF19 (NP_056250, 739 a.a. ~ 837 a.a) partial recombinant protein with GST tag. The sequence is MKTSCSHGSSDYHTRFATVNILPEVENDRLENSPHQCSISVVTQTASCSEVSQLNHIAEE HGNNGIKPNVDLYFGDALKETNNNHSHQTMELKVAIQTE

Conjugate

Alternative Names

RNF19A; ring finger protein 19A, RBR E3 ubiquitin protein ligase; RNF19; E3 ubiquitin-protein ligase RNF19A; ring finger protein 19; double ring-finger protein; ring-IBR-ring domain containing protein Dorfin; ring finger protein 19A, E3 ubiquitin protein

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a member of the ring between ring fingers (RBR) protein family, and the encoded protein contains two RING-finger motifs and an in between RING fingers motif. This protein is an E3 ubiquitin ligase that is localized to Lewy bodies, and ubiquitylates synphilin-1, which is an interacting protein of alpha synuclein in neurons. The encoded protein may be involved in amyotrophic lateral sclerosis and Parkinsons disease. Alternative splicing results in multiple transcript variants.

Pathway

Parkin-Ubiquitin Proteasomal System pathway;