Anti-RNF103 (aa 501-599) polyclonal antibody

Species Reactivity

Human

Immunogen

RNF103 (NP_005658, 501 a.a. ~ 599 a.a) partial recombinant protein with GST tag. The sequence is HPLIPTDYIKNLPMWRFKCLGVQSEEEMSEGSQDTENDSESENTDTLSSEKEVFEDKQSV LHNSPGTASHCDAEACSCANKYCQTSPCERKGRSYGSYN

Conjugate

Alternative Names

RNF103; ring finger protein 103; KF1; KF-1; HKF-1; ZFP103; ZFP-103; E3 ubiquitin-protein ligase RNF103; zinc finger protein 103 homolog; zinc finger protein expressed in cerebellum;

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene contains a RING-H2 finger, a motif known to be involved in protein-protein and protein-DNA interactions. This gene is highly expressed in normal cerebellum, but not in the cerebral cortex. The expression of the rat counterpart in the frontal cortex and hippocampus was shown to be induced by elctroconvulsive treatment (ECT) as well as chronic antidepressant treatment, suggesting that this gene may be a molecular target for ECT and antidepressants. The protein is a ubiquitin ligase that functions in the endoplasmic reticulum-associated degradation pathway. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream CHMP3 (charged multivesicular body protein 3) gene.