Anti-RND1 monoclonal antibody (DCABH-838)

Mouse anti-Human RND1 monoclonal antibody for WB, FC, ICC/IF Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
2D4
Species Reactivity
Human
Immunogen
Recombinant full length Human RND1 produced in HEK293T cells (NP_055285).
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/2000; Flow Cyt: 1/100; ICC/IF: 1/100;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
RND1; Rho family GTPase 1; rho-related GTP-binding protein Rho6; ARHS; ras homolog gene family; member S
Entrez Gene ID
UniProt ID

Product Background


Gene summary
RND1 (Rho Family GTPase 1) is a Protein Coding gene. Diseases associated with RND1 include alcoholic psychosis and alcohol-induced mental disorder. Among its related pathways are Developmental Biology and Axon guidance. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RHOA. This gene encodes a protein that belongs to the Rho GTPase family. Members of this family regulate the organization of the actin cytoskeleton in response to extracellular growth factors. A similar protein in rat interacts with a microtubule regulator to control axon extension.
Antigen Description
Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments. Rnd1 is a small (~21 kDa) signaling G protein (to be specific, a GTPase), and is a member of the Rnd subgroup of the Rho family of GTPases. It is encoded by the gene RND1. 0The function about RND1 antigen include GTP binding; GTPase activity; nucleotide binding; protein binding; receptor binding.
Pathway
Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; Developmental Biology, organism-specific biosystem; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion, organism-specific biosystem; Sema4D in semaphorin signaling, organism-specific biosystem; Sema4D induced cell migration and growth-cone collapse, organism-specific biosystem.

Citations


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References


Oinuma, I; Katoh, H; et al. Molecular dissection of the semaphorin 4D receptor Plexin-B1-stimulated R-Ras GTPase-activating protein activity and neurite remodeling in hippocampal neurons. JOURNAL OF NEUROSCIENCE 24:11473-11480(2004).

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