Anti-RNASEL polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Mouse

Immunogen

Synthetic peptide within Mouse RNase L aa 139-167 (N terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.Database link: Q05921

Conjugate

Unconjugated

Application Notes

WB: 1/100 - 1/500;

Alternative Names

RNASEL; ribonuclease L (2, 5-oligoisoadenylate synthetase-dependent); E230029I04Rik; 2-5A-dependent ribonuclease; RNase L; ribonuclease 4; 2-5A-dependent RNase; 2-5A-dependent RNAase;

Entrez Gene ID

24014

UniProt ID

B2RQP1

Antigen Description

Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. Might play a central role in the regulation of mRNA turnover.

Pathway

Hepatitis C; Herpes simplex infection; Influenza A; Senescence and Autophagy

We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More