Anti-RNA polymerase II monoclonal antibody (DMAB6568)

Mouse anti-RNA polymerase II monoclonal antibody for WB Datasheet

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Host Species
Antibody Isotype
Species Reactivity
Purified RNA polymerase II.


Alternative Names
RNA polymerase II; RPB1; RPB2; RPB3; RPB4; RPB5

Product Background

Antigen Description
The eukaryotic core RNA polymerase II was first purified using transcription assays. The purified enzyme has typically 10-12 subunits (12 in humans and yeast) and is incapable of specific promoter recognition. Many subunit-subunit interactions are known. RPB3 is involved in RNA polymerase II assembly. A subcomplex of RPB2 and RPB3 appears soon after subunit synthesis. This complex subsequently interacts with RPB1. RPB3, RPB5, and RPB7 interact with themselves to form homodimers, and RPB3 and RPB5 together are able to contact all of the other RPB subunits, except RPB9. Only RPB1 strongly binds to RPB5. The RPB1 subunit also contacts RPB7, RPB10, and more weakly but most efficiently with RPB8. Once RPB1 enters the complex, other subunits such as RPB5 and RPB7 can enter, where RPB5 binds to RPB6 and RPB8 and RPB3 brings in RPB10, RPB 11, and RPB12. RPB4 and RPB9 may enter once most of the complex is assembled. RPB4 forms a complex with RPB7.


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Storck, S; Aoufouchi, S; et al. AID and partners: for better and (not) for worse. CURRENT OPINION IN IMMUNOLOGY 23:337-344(2011).
Hattori, N; Niwa, T; et al. Visualization of multivalent histone modification in a single cell reveals highly concerted epigenetic changes on differentiation of embryonic stem cells. NUCLEIC ACIDS RESEARCH 41:7231-7239(2013).

Custom Antibody Labeling

We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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