Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.
Pathway
Calcium Regulation in the Cardiac Cell; G alpha (i) signalling events; G alpha (z) signalling events; GPCR downstream signaling; Myometrial Relaxation and Contraction Pathways; Signal Transduction; Signaling by GPCR
Citations
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