General Notes
This product (Catalog No. DPABH-26345) is a rabbit-derived polyclonal antibody raised against human RGS4, targeting the amino acid region 38–205 of the protein. This antibody exhibits cross-reactivity with Human RGS4 from mouse and rat. It has been affinity purified by Protein A. Regulator of G protein signaling 4 (RGS4) is a protein encoded by the human RGS4 gene that functions as a GTPase-activating protein (GAP) for the alpha subunits of Gi, Go, and Gq family heterotrimeric G proteins, accelerating their GTP hydrolysis to terminate downstream signaling pathways initiated by G protein-coupled receptors (GPCRs). As a member of the RGS protein family, RGS4 contains a conserved RGS domain of approximately 120 amino acids responsible for its GAP activity, along with an N-terminal region that confers specificity for certain GPCRs, such as the M3 muscarinic acetylcholine receptor. The protein exists in multiple isoforms due to alternative splicing, with the longest isoform featuring a 205-amino-acid sequence that localizes primarily to the cytoplasm.
DPABH-26345 is suitable for use in ELISA (1:4,000–1:8,000), IHC (1:50–1:100), Western blot (WB) (1:1,000–1:4,000) applications.
DPABH-26345 is supplied as a liquid formulation in 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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