General Notes
This product (Catalog No. DPABH-05315) is a rabbit-derived polyclonal antibody raised against human RGS2, targeting the amino acid region 73–201 of the protein. It has been affinity purified by Protein A. Regulator of G Protein Signaling 2 (RGS2) is a 212-amino-acid protein encoded by the RGS2 gene on human chromosome 1, belonging to the B/R4 subfamily of regulators of G protein signaling (RGS) proteins. It functions primarily as a GTPase-activating protein (GAP) that accelerates the hydrolysis of GTP to GDP on the α-subunits of heterotrimeric G proteins, particularly those in the Gq/11 class, thereby terminating G protein-coupled receptor (GPCR) signaling and preventing prolonged activation of downstream effectors like phospholipase Cβ (PLCβ). Beyond its GAP activity, RGS2 exhibits non-canonical roles, including direct inhibition of certain adenylyl cyclase isoforms and modulation of protein synthesis through interactions with elongation factor 2b.
DPABH-05315 is suitable for use in ELISA (1:4,000–1:8,000), IHC (1:50–1:100), Western blot (WB) (1:1,000–1:4,000) applications.
DPABH-05315 is supplied as a liquid formulation in 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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