Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Associates specifically with the activated forms of the G protein subunits G(i)-alpha and G(z)-alpha but fails to interact with the structurally and functionally distinct G(s)-alpha subunit. Activity on G(z)-alpha is inhibited by palmitoylation of the G-protein.
Pathway
Calcium Regulation in the Cardiac Cell; G alpha (i) signalling events; GPCR downstream signaling; Myometrial Relaxation and Contraction Pathways; Signal Transduction; Signaling by GPCR;
Citations
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