Specifications
Immunogen
Synthetic peptide, corresponding to residues of Human RGS10 (UniProt: O43665).
Applications
Application Notes
WB: 1/1000 - 1/10000; IHC-P: 1/50 - 1/100; ICC/IF: 1/50 - 1/100; IP: 1/10 - 1/100;
Target
Alternative Names
RGS10; regulator of G-protein signaling 10; regulator of G protein signalling 10; regulator of G-protein signalling 10;
Product Background
Antigen Description
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Associates specifically with the activated forms of the G protein subunits G(i)-alpha and G(z)-alpha but fails to interact with the structurally and functionally distinct G(s)-alpha subunit. Activity on G(z)-alpha is inhibited by palmitoylation of the G-protein.
Pathway
Calcium Regulation in the Cardiac Cell, organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; Myometrial Relaxation and Contraction Pathways, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signaling by GPCR, organism-specific biosystem.
Citations
Publication ()
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COA
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