This gene encodes a member of the short-chain dehydrogenase/reductase family. The encoded protein catalyzes the reduction of all-trans-retinal to all-trans-retinol, the first reaction step of the rhodopsin regeneration pathway. This enzymatic reaction is the rate-limiting step in the visual cycle.
Pathway
Disease; Diseases associated with visual transduction; Retinol metabolism; Retinol metabolism; Signal Transduction; The canonical retinoid cycle in rods (twilight vision); Visual phototransduction; Vitamin A and carotenoid metabolism; retinol biosynthesis;the visual cycle I (vertebrates);
Citations
Publication ()
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