Anti-RBBP4 monoclonal antibody, clone FQS4523

Antibody Isotype

IgG

Clone

FQS4523

Species Reactivity

Human

Immunogen

A synthetic peptide corresponding to residues in human RbAp48.

Conjugate

Alternative Names

RBBP4; retinoblastoma binding protein 4; histone-binding protein RBBP4; NURF55; RbAp48; RBBP-4; CAF-I p48; CAF-1 subunit C; CAF-I 48 kDa subunit; MSI1 protein homolog; retinoblastoma-binding protein 4; retinoblastoma-binding protein p48; chromatin assembl

Entrez Gene ID

UniProt ID

Antigen Description

Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.

Pathway

Cell Cycle, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; Chromosome Maintenance, organism-specific biosystem; Deposition of New CENPA-containing Nucleosomes at the Centromere, organism-specific biosystem; E2F transcription factor network, organism-specific biosystem; G0 and Early G1, organism-specific biosystem; Hedgehog signaling events mediated by Gli proteins, organism-specific biosystem;