Anti-RAD51B monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthetic peptide of human RAD51L1 is used for rabbit immunization.

Conjugate

Alternative Names

RAD51B; RAD51 paralog B; REC2; R51H2; RAD51L1; DNA repair protein RAD51 homolog 2; RAD51 homolog B; RecA-like protein; recombination repair protein;

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts with the other family members, such as RAD51, XRCC2, and XRCC3. Overexpression of this gene was found to cause cell cycle G1 delay and cell apoptosis, which suggested a role of this protein in sensing DNA damage. At least three alternatively spliced transcript variants encoding distinct isoforms have been observed. Rearrangements between this locus and high mobility group AT-hook 2 (HMGA2, GeneID 8091) have been observed in uterine leiomyomata.

Pathway

Factors involved in megakaryocyte development and platelet production; Hemostasis; Homologous recombination;