General Notes
This product (Catalog No. DPABH-25214) is a rabbit-derived polyclonal antibody raised against human RAB5A, targeting the amino acid region 136–215 of the protein. This antibody exhibits cross-reactivity with Human RAB5A from mouse and rat. It has been affinity purified by Protein A. AB5A is a protein-coding gene located on chromosome 3p24.3 in humans that encodes ras-related protein Rab-5A, a small GTPase belonging to the RAS oncogene family and a principal component of early endosomes. As a molecular switch cycling between inactive GDP-bound and active GTP-bound states, Rab5A regulates the kinetics of membrane traffic in the early endocytic pathway, including the fusion of endocytic vesicles with early endosomes and transport from the plasma membrane. It enables GDP and GTP binding as well as GTPase activity (EC 3.6.5.2) and is essential for processes such as endosome biogenesis, phagosome maturation, and cargo sorting.
DPABH-25214 is suitable for use in ELISA (1:4,000–1:8,000), IHC (1:50–1:100), Western blot (WB) (1:1,000–1:4,000) applications.
DPABH-25214 is supplied as a liquid formulation in 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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