Rabbit Anti-Human PHEX Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human; Mouse

Immunogen

A synthesized peptide derived from human PHEX.

Conjugate

Application Notes

WB 1:500-1:2000
IF/ICC 1:100-1:500
IHC 1:50-1:200

General Notes

This product (Catalog No. DPABH-24684) is a rabbit-derived polyclonal antibody raised against human PHEX. This antibody exhibits cross-reactivity with PHEX from mouse. It has been affinity purified by Protein A. Peptidase that cleaves SIBLING (small integrin-binding ligand, N-linked glycoprotein)-derived ASARM peptides, thus regulating their biological activity. Cleaves ASARM peptides between Ser and Glu or Asp residues. Regulates osteogenic cell differentiation and bone mineralization through the cleavage of the MEPE-derived ASARM peptide. Promotes dentin mineralization and renal phosphate reabsorption by cleaving DMP1- and MEPE-derived ASARM peptides. Inhibits the cleavage of MEPE by CTSB/cathepsin B thus preventing MEPE degradation.
DPABH-24684 is suitable for use in WB 1 (500-1:2000), IF/ICC 1 (100-1:500), IHC 1 (50-1:200) applications.
DPABH-24684 is supplied as a liquid formulation in Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Entrez Gene ID

UniProt ID