General Notes
This product (Catalog No. DPABH-19481) is a rabbit-derived polyclonal antibody raised against human PHEX, targeting the amino acid region 430–641 of the protein. This antibody exhibits cross-reactivity with Human PHEX from mouse, rat, and hamster. It has been affinity purified by Protein A. Phex encodes a 100- to 105-kDa transmembrane glycoprotein, which is present in bones and teeth of normal mice but not Hyp animals. Phex protein expression in femur and calvaria decreases with age, high levels of Phex detected in osteocytes make this protein an interesting marker to study the later stages of osteoblastic cell differentiation (PMID: 10934642). The 76 kDa represents the deglycosylated core-glycosylated forms within the ERs, the 95 kDa represents the core-glycosylated and unmatured form within the ERs, the 105 kDa species of PHEX protein represents the fully processed, matured for(PMID: 3251189, 35654784).
DPABH-19481 is suitable for use in Western blot (WB) (1:500–1:2,000) application.
DPABH-19481 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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