PURA (NP_005850, 183 a.a. ~ 292 a.a) partial recombinant protein with GST tag. The sequence is TQGQTIALPAQGLIEFRDALAKLIDDYGVEEEPAELPEGTSLTVDNKRFFFDVGSNKYGV FMRVSEVKPTYRNSITVPYKVWAKFGHTFCKYSEETKKIQEKQREKRAAC
Conjugate
Unconjugated
Target
Alternative Names
PURA; purine-rich element binding protein A; PUR1; PURALPHA; PUR-ALPHA; transcriptional activator protein Pur-alpha; purine-rich single-stranded DNA-binding protein alpha;
This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia.
Pathway
Diurnally regulated genes with circadian orthologs.
Citations
Publication ()
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COA
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