Anti-PTPLA monoclonal antibody (DCABH-13121) Made to order

Rabbit anti-Human PTPLA monoclonal antibody for WB, ELISA

View other PTPLA antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human PTPLA is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
PTPLA; protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A; protein tyrosine phosphatase like (proline instead of catalytic arginine), member a; 3-hydroxyacyl-CoA dehydratase 1; CAP; cementum attachment protein
Entrez Gene ID
UniProt ID

Product Background


Gene summary
HACD1 (3-Hydroxyacyl-CoA Dehydratase 1) is a Protein Coding gene. Diseases associated with HACD1 include cataract 32, multiple types and congenital fiber-type disproportion. Among its related pathways are Metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include enzyme binding and lyase activity. An important paralog of this gene is HACD4. The protein encoded by this gene contains a characteristic catalytic motif of the protein tyrosine phosphatases (PTPs) family. The PTP motif of this protein has the highly conserved arginine residue replaced by a proline residue; thus it may represent a distinct class of PTPs. Members of the PTP family are known to be signaling molecules that regulate a variety of cellular processes. This gene was preferentially expressed in both adult and fetal heart. A much lower expression level was detected in skeletal and smooth muscle tissues, and no expression was observed in other tissues. The tissue specific expression in the developing and adult heart suggests a role in regulating cardiac development and differentiation.
Antigen Description
The protein encoded by this gene contains a characteristic catalytic motif of the protein tyrosine phosphatases (PTPs) family. The PTP motif of this protein has the highly conserved arginine residue replaced by a proline residue; thus it may represent a distinct class of PTPs. Members of the PTP family are known to be signaling molecules that regulate a variety of cellular processes. This gene was preferentially expressed in both adult and fetal heart. A much lower expression level was detected in skeletal and smooth muscle tissues, and no expression was observed in other tissues. The tissue specific expression in the developing and adult heart suggests a role in regulating cardiac development and differentiation. Myopathy, congenital, with fiber-type disproportion (CFTD) [MIM:255310]: A genetically heterogeneous disorder in which there is relative hypotrophy of type 1 muscle fibers compared to type 2 fibers on skeletal muscle biopsy. However, these findings are not specific and can be found in many different myopathic and neuropathic conditions. Note=The gene represented in this entry may be involved in disease pathogenesis. A loss-of-function mutation that segregates with the disease was found in four members of a consanguineous family and not identified in unaffected controls. The mutation affects the expression of the mRNA and the produced protein is catalytically inactive. The function about PTPLA antigen include lyase activity; protein tyrosine phosphatase activity.
Pathway
Biosynthesis of unsaturated fatty acids, organism-specific biosystem; Biosynthesis of unsaturated fatty acids, conserved biosystem; Fatty acid biosynthesis, elongation, endoplasmic reticulum, organism-specific biosystem; Fatty acid biosynthesis, elongation, endoplasmic reticulum, conserved biosystem; Fatty acid elongation, organism-specific biosystem; Fatty acid elongation, conserved biosystem.

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References


Molecular cloning, chromosomal mapping, and developmental expression of a novel protein tyrosine phosphatase-like gene

GENOMICS

Authors: Uwanogho, DA; Hardcastle, Z; Balogh, P; Mirza, G; Thornburg, KL; Ragoussis, J; Sharpe, PT

Protein tyrosine phosphatases (PTPs) mediate the dephosphorylation of phosphotyrosine, PTPs are known to be involved in many signal transduction pathways leading to cell growth, differentiation, and oncogenic transformation. We have cloned a new family of novel protein tyrosine phosphatase-like genes, the Ptpl (protein tyrosine phosphatase-like; proline instead of catalytic arginine) gene family. This gene family is composed of at least three members, and we describe here the developmental expression pattern and chromosomal location for one of these genes, Ptpla. In situ hybridization studies revealed that Ptpla expression was first detected at embryonic day 8.5 in muscle progenitors and later in differentiated muscle types: in the developing heart, throughout the liver and lungs, and in a number of neural crest derivatives including the dorsal root and trigeminal ganglia. Postnatally Ptpla was expressed in a number of adult tissues including cardiac and skeletal muscle, liver, testis, and kidney. The early expression pattern of this gene and its persistent expression in adult tissues suggest that it may have an important role in the development, differentiation, and maintenance of a number of different tissue types. The human homologue of Ptpla (PTPLA) was cloned and shown to map to 10p13-p14. (C) 1999 Academic Press.

Expression Map of the Human Exome in CD34+Cells and Blood Cells: Increased Alternative Splicing in Cell Motility and Immune Response Genes

PLOS ONE

Authors: Tondeur, Sylvie; Pangault, Celine; Le Carrour, Tanguy; Lannay, Yoann; Benmahdi, Rima; Cubizolle, Aurelie; Assou, Said; Pantesco, Veronique; Klein, Bernard; Hamamah, Samir; Schved, Jean-Francois; Fest, Thierry; De Vos, John

Background: Hematopoietic cells are endowed with very specific biological functions, including cell motility and immune response. These specific functions are dramatically altered during hematopoietic cell differentiation, whereby undifferentiated hematopoietic stem and progenitor cells (HSPC) residing in bone marrow differentiate into platelets, red blood cells and immune cells that exit into the blood stream and eventually move into lymphoid organs or inflamed tissues. The contribution of alternative splicing (AS) to these functions has long been minimized due to incomplete knowledge on AS events in hematopoietic cells. Principal Findings: Using Human Exon ST 1.0 microarrays, the entire exome expression profile of immature CD34+ HSPC and mature whole blood cells was mapped, compared to a collection of solid tissues and made freely available as an online exome expression atlas (Amazonia Exon! : http://amazonia.transcriptome.eu/exon.php). At a whole transcript level, HSPC strongly expressed EREG and the pluripotency marker DPPA4. Using a differential splicing index scheme (dsi), a list of 849 transcripts differentially expressed between hematopoietic cells and solid tissues was computed, that included NEDD9 and CD74. Some of these genes also underwent alternative splicing events during hematopoietic differentiation, such as INPP4B, PTPLA or COMMD6, with varied contribution of CD3+ T cells, CD19+ B cells, CD14+ or CD15+ myelomonocytic populations. Strikingly, these genes were significantly enriched for genes involved in cell motility, cell adhesion, response to wounding and immune processes. Conclusion: The relevance and the precision provided by this exon expression map highlights the contribution of alternative splicing to key feature of blood cells differentiation and function.

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