Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.
Pathway
Class A/1 (Rhodopsin-like receptors); G alpha (s) signalling events; GPCR ligand binding; Inflammatory mediator regulation of TRP channels
Citations
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