Anti-PTGER4 (aa 379-488) polyclonal antibody

Species Reactivity

Human

Immunogen

PTGER4 (NP_000949, 379 a.a. ~ 488 a.a) partial recombinant protein with GST tag. The sequence is SFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPGMGLAQEDTTSLRTLRISE TSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSETLNLSEKCI

Conjugate

Alternative Names

PTGER4; prostaglandin E receptor 4 (subtype EP4); EP4; EP4R; prostaglandin E2 receptor EP4 subtype; prostanoid EP4 receptor; PGE receptor EP4 subtype; PGE receptor, EP4 subtype; PGE2 receptor EP4 subtype;

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses.

Pathway

Class A/1 (Rhodopsin-like receptors); G alpha (s) signalling events; GPCR ligand binding; Inflammatory mediator regulation of TRP channels