Anti-PTBP3 monoclonal antibody (DMAB12751)
Mouse anti-PTBP3 monoclonal antibody for WB, IHC, IF, ELISA
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Human, Mouse, Rat
ROD1 (NP_005147, 16 a.a. ~ 114 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
PTBP3 (Polypyrimidine Tract Binding Protein 3) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is ENSG00000268083. The protein encoded by this gene binds RNA and is a regulator of cell differentiation. The encoded protein preferentially binds to poly(G) and poly(U) sequences in vitro. Several transcript variants encoding different isoforms have been found for this gene.
RNA-binding protein that mediates pre-mRNA alternative splicing regulation. Plays a role in the regulation of cell proliferation, differentiation and migration. Positive regulator of EPO-dependent erythropoiesis. Participates in cell differentiation regulation by repressing tissue-specific exons. Promotes FAS exon 6 skipping. Binds RNA, preferentially to both poly(G) and poly(U). The function about PTBP3 antigen include RNA binding;nucleotide binding.
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Chung, RT; Kaplan, LM; et al. Heterogeneous nuclear ribonucleoprotein I (hnRNP-I/PTB) selectively binds the conserved 3 ' terminus of hepatitis C viral RNA. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 254:351-362(1999).
Ashiya, M; Grabowski, PJ; et al. A neuron-specific splicing switch mediated by an array of pre-mRNA repressor sites: Evidence of a regulatory role for the polypyrimidine tract binding protein and a brain-specific PTB counterpart. RNA-A PUBLICATION OF THE RNA SOCIETY 3:996-1015(1997).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.