Anti-PTBP3 monoclonal antibody (DMAB12751)

Mouse anti-PTBP3 monoclonal antibody for WB, IHC, IF, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
5D0
Species Reactivity
Human, Mouse, Rat
Immunogen
ROD1 (NP_005147, 16 a.a. ~ 114 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
ROD1
Entrez Gene ID
UniProt ID

Product Background


Gene summary
PTBP3 (Polypyrimidine Tract Binding Protein 3) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is ENSG00000268083. The protein encoded by this gene binds RNA and is a regulator of cell differentiation. The encoded protein preferentially binds to poly(G) and poly(U) sequences in vitro. Several transcript variants encoding different isoforms have been found for this gene.
Antigen Description
RNA-binding protein that mediates pre-mRNA alternative splicing regulation. Plays a role in the regulation of cell proliferation, differentiation and migration. Positive regulator of EPO-dependent erythropoiesis. Participates in cell differentiation regulation by repressing tissue-specific exons. Promotes FAS exon 6 skipping. Binds RNA, preferentially to both poly(G) and poly(U). The function about PTBP3 antigen include RNA binding;nucleotide binding.

Citations


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References


Lutz, CS; Cooke, C; et al. The snRNP-free U1A (SF-A) complex(es): Identification of the largest subunit as PSF, the polypyrimidine-tract binding protein-associated splicing factor. RNA-A PUBLICATION OF THE RNA SOCIETY 4:1493-1499(1998).
KHELLIL, S; DAUGERON, MC; et al. THE 5' END DOMAIN OF U2 SNRNA IS REQUIRED TO ESTABLISH THE INTERACTION OF U2 SNRNP WITH U2 AUXILIARY FACTOR(S) DURING MAMMALIAN SPLICEOSOME ASSEMBLY. NUCLEIC ACIDS RESEARCH 19:877-884(1991).

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We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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