General Notes
This product (Catalog No. DPABH-10722) is a rabbit-derived polyclonal antibody raised against human PTBP3, targeting the amino acid region 356–552 of the protein. It has been affinity purified by Protein A. PTBP3 (polypyrimidine tract binding protein 3) is an RNA-binding protein belonging to the heterogeneous nuclear ribonucleoprotein (hnRNP) family and a paralog of PTBP1. It regulates alternative splicing by binding to polypyrimidine-rich sequences within pre-mRNA, thereby influencing exon inclusion or skipping in a context-dependent manner. PTBP3 is preferentially expressed in hematopoietic cells and during erythroid differentiation, where it modulates lineage-specific splicing programs. Beyond splicing control, PTBP3 also contributes to mRNA stability and post-transcriptional regulation. Dysregulated PTBP3 expression has been implicated in tumor progression and metastasis in several cancers, where it can alter oncogenic splicing networks and cellular proliferation pathways.
DPABH-10722 is suitable for use in ELISA (1:4,000–1:8,000), IHC (1:50–1:100), Western blot (WB) (1:1,000–1:4,000) applications.
DPABH-10722 is supplied as a liquid formulation in 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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