Synthetic peptide corresponding to N terminal amino acids 1-50 (VLESTMVCVD NSEYMRNGDF LPTRLQAQQD AVNIVCHSKT RSNPENNVGL) of Human Proteasome 19S S5A (NP_002801).
Binds and presumably selects ubiquitin-conjugates for destruction. Displays selectivity for longer polyubiquitin chains. Modulates intestinal fluid secretion.
Pathway
APC/C-mediated degradation of cell cycle proteins; APC/C:Cdc20 mediated degradation of mitotic proteins; AUF1 (hnRNP D0) destabilizes mRNA; Activation of NF-kappaB in B cells
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