Anti-PSMD4 monoclonal antibody, clone BI2.2

Antibody Isotype

IgG1

Clone

BI2.2

Species Reactivity

Human; Pig; Xenopus laevis

Immunogen

Sub unit 5a.

Conjugate

Application Notes

Flow Cyt: 1μg/10⁶ cells; ICC/IF: 1/200; IHC-Fr: 1/100; IP: 5 μg/ml.

Alternative Names

PSMD4; proteasome (prosome, macropain) 26S subunit, non-ATPase, 4; 26S proteasome non-ATPase regulatory subunit 4; AF; AF 1; Rpn10; S5A; angiocidin; RPN10 homolog; antisecretory factor 1; S5a/antisecretory factor protein; multiubiquitin chain-binding prot

Entrez Gene ID

UniProt ID

Antigen Description

Binds and presumably selects ubiquitin-conjugates for destruction. Displays selectivity for longer polyubiquitin chains. Modulates intestinal fluid secretion.

Pathway

APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem; APC/C:Cdc20 mediated degradation of Securin, organism-specific biosystem; APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystem; Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem; Activation of NF-kappaB in B Cells, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem;