A region within synthetic peptide: MDRLLRLGGG MPGLGQGPPT DAPAVDTAEQ VYISSLALLK MLKHGRAGVP, corresponding to N terminal amino acids 1-50 of Human PSMD14
Metalloprotease component of the 26S proteasome that specifically cleaves Lys-63-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The function of the Lys-63-specific deubiquitination of the proteasome is unclear.
Pathway
APC/C-mediated degradation of cell cycle proteins; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdc20 mediated degradation of mitotic proteins; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;
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