Synthetic peptide within residues: VGIKAANGVV LATEKKQKSI LYDERSVHKV EPITKHIGLV YSGMGPDYRV , corresponding to N terminal amino acids 36-85 of Human Proteasome 20S alpha 2 (NP_002778)
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. PSMA2 may have a potential regulatory effect on another component(s) of the proteasome complex through tyrosine phosphorylation.
Pathway
APC/C-mediated degradation of cell cycle proteins; APC/C:Cdc20 mediated degradation of mitotic proteins; AUF1 (hnRNP D0) destabilizes mRNA; Activation of NF-kappaB in B cells
Citations
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