Anti-PSMA2 monoclonal antibody, clone FQS6565

Antibody Isotype

IgG

Clone

FQS6565

Species Reactivity

Mouse; Rat; Human

Immunogen

Synthetic peptide (Human)

Conjugate

Application Notes

WB: 1/10000 - 1/50000; Flow Cyt: 1/10 - 1/100;

Alternative Names

PSMA2; proteasome (prosome, macropain) subunit, alpha type, 2; proteasome subunit alpha type-2; HC3; MU; PMSA2; macropain subunit C3; proteasome subunit HC3; proteasome component C3; multicatalytic endopeptidase complex subunit C3; PSC2;

Entrez Gene ID

UniProt ID

Antigen Description

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. PSMA2 may have a potential regulatory effect on another component(s) of the proteasome complex through tyrosine phosphorylation.

Pathway

APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem; APC/C:Cdc20 mediated degradation of Securin, organism-specific biosystem; APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystem; Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem; Activation of NF-kappaB in B Cells, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem;