ELISA (1:10000); WB (1:500-1:2000); Immunohistochemistry (1:200-1:1000); Immunofluorescence (1:200-1:1000) & The optimal working dilution should be determined by the end user.
Target
Alternative Names
PSIP1; PC4 and SFRS1 interacting protein 1; PC4 and SFRS1 interacting protein 2 , PSIP2; PC4 and SFRS1-interacting protein; LEDGF; p52; p75; DFS 70; CLL-associated antigen KW-7; dense fine speckles 70 kDa protein; transcriptional coactivator p52/p75; tran
Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration.
Pathway
2-LTR circle formation, organism-specific biosystem; APOBEC3G mediated resistance to HIV-1 infection, organism-specific biosystem; Autointegration results in viral DNA circles, organism-specific biosystem; Disease, organism-specific biosystem; Early Phase
Citations
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