General Notes
This product (Catalog No. DPABH-13526) is a rabbit-derived polyclonal antibody raised against human PSAP, targeting the amino acid region 17–524 of the protein. It has been affinity purified by Protein A. Prosaposin (PSAP), encoded by the PSAP gene on human chromosome 10q22.1, is a multifunctional glycoprotein that serves as the precursor to four sphingolipid activator proteins known as saposins A, B, C, and D. These saposins are generated through proteolytic cleavage of the 524-amino-acid PSAP precursor by lysosomal proteases such as cathepsin D, and each plays a specific role in activating hydrolases that degrade glycosphingolipids in lysosomes, thereby maintaining cellular lipid homeostasis. Beyond its primary lysosomal function, intact PSAP exhibits extracellular neurotrophic, immunomodulatory, and signaling properties, influencing neuronal survival, inflammation resolution, and metabolic processes across various tissues.
DPABH-13526 is suitable for use in ELISA (1:4,000–1:8,000), IHC (1:50–1:100), Western blot (WB) (1:1,000–1:4,000) applications.
DPABH-13526 is supplied as a liquid formulation in 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
Alternative Names
Dispersin; SAP1; Prosaposin; SAP-1; Sulfatide/GM1 activator; Proactivator polypeptide; SAP-2; Protein C; Sphingolipid activator protein 1; CSAct; PSAP; GLBA; Sphingolipid activator protein 2; Co-beta-glucosidase; Cerebroside sulfate activator; Component C; A1 activator; Protein A; Glucosylceramidase activator
COA
Publication 
Loading ......
