Anti-PRSS2 monoclonal antibody, clone FQS22776(C)

Antibody Isotype

IgG

Clone

FQS22776(C)

Species Reactivity

Mouse; Rat; Human

Immunogen

Synthetic peptide corresponding to residues in Human Trypsinogen (UniProt: P07478).

Conjugate

Application Notes

WB: 1/1000 - 1/10000.

Alternative Names

PRSS2; protease, serine, 2 (trypsin 2); trypsin-2; TRY2; trypsin 2; trypsin II; trypsinogen 2; serine protease 2; anionic trypsinogen; protease serine 2 preproprotein; protease, serine, 2, preproprotein; TRY8; TRYP2; MGC111183; MGC120174; MGC120175;

Entrez Gene ID

UniProt ID

Antigen Description

Trypsinogen has been shown to have certain intrinsic activity. It is usually considered, however, as the inactive precursor of trypsin which may be activated by removal of a terminal hexapeptide to yield single chain b trypsin. Subsequent limited autolysis produces other active forms having two or more peptide chains bound by disulfide bonds. The predominant forms are a trypsin, having two peptide chains and b, a single chain. Different activity and thermal stability are shown by a and b trypsin.

Pathway

Activation of Matrix Metalloproteinases, organism-specific biosystem; Alpha-defensins, organism-specific biosystem; Defensins, organism-specific biosystem; Degradation of the extracellular matrix, organism-specific biosystem; Extracellular matrix organization, organism-specific biosystem; Immune System, organism-specific biosystem; Influenza A, organism-specific biosystem;