Product Overview
Mouse myeloma cell line, NS0-derived human Trypsin 2/PRSS2 protein, Ala16-Ser247, with a C-terminal 10-His tag.
Predicted N terminal
Ala16
Molecular Weight
Predicted Molecular Mass: 26 kDa
SDS-PAGE: 34 kDa, reducing conditions
Bio-activity
Measured by its ability to cleave the fluorogenic peptide substrate, Mca-RPKPVE-Nval-WRK(Dnp)-NH2. The specific activity is >8,000 pmol/min/μg.
Endotoxin
<1.0 EU per 1 μg of the protein by the LAL method.
Alternative Names
Serine protease 2; Trypsin-2; Anionic trypsinogen; Trypsin II; PRSS2; TRY2; TRYP2
Purity
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Buffer
Supplied as a 0.2 μm filtered solution in HCl and NaCl.
Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -70°C as supplied. 3 months, -70 °C under sterile conditions after opening.
Introduction
PRSS2 is a gene that encodes for anionic trypsinogen, a form of the digestive enzyme trypsin, which is found in high levels in pancreatic juice. It is a serine protease that cleaves peptide bonds following lysine or arginine residues. The PRSS2 gene is associated with conditions such as pancreatitis and plays a role in the progression of certain cancers by influencing enzymes like MMP-9 and interacting with other proteins in the tumor microenvironment.
Keywords
Serine protease 2; Trypsin-2; Anionic trypsinogen; Trypsin II; PRSS2; TRY2; TRYP2
Citations
Publication ()
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COA
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