Anti-PRICKLE1 (aa 684-756) polyclonal antibody

Species Reactivity

Human

Immunogen

PRICKLE1 (NP_694571, 684 a.a. ~ 756 a.a) partial recombinant protein with GST tag. The sequence is DNALNLVTERKYSPKDRLRLYTPDNYEKFIQNKSAREIQAYIQNADLYGQYAHATPDYGL QNPGMNRFLGLYG

Conjugate

Alternative Names

PRICKLE1; prickle homolog 1 (Drosophila); RILP; EPM1B; prickle-like protein 1; prickle-like 1; REST/NRSF-interacting LIM domain protein 1; REST (RE-1 silencing transcription factor)/NRSF (neuron-restrictive silencer factor)-interacting LIM domain protein;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a nuclear receptor that may be a negative regulator of the Wnt/beta-catenin signaling pathway. The encoded protein localizes to the nuclear membrane and has been implicated in the nuclear trafficking of the transcription repressors REST/NRSF and REST4. Mutations in this gene have been linked to progressive myoclonus epilepsy. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 3.

Pathway

Asymmetric localization of PCP proteins; Signal Transduction; Wnt signaling pathway; beta-catenin independent WNT signaling