Anti-PRICKLE1 monoclonal antibody, clone 9H6

Antibody Isotype

IgG2b

Clone

9H6

Species Reactivity

Human

Immunogen

PRICKLE1 (NP_694571, 684 a.a. ~ 756 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Conjugate

Alternative Names

PRICKLE1; prickle homolog 1 (Drosophila); prickle like 1 (Drosophila); prickle-like protein 1; EPM1B; FLJ31937; prickle-like 1; REST/NRSF-interacting LIM domain protein 1; REST (RE-1 silencing transcription factor)/NRSF (neuron-restrictive silencer factor

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a nuclear receptor that may be a negative regulator of the Wnt/beta-catenin signaling pathway. The encoded protein localizes to the nuclear membrane and has been implicated in the nuclear trafficking of the transcription repressors REST/NRSF and REST4. Mutations in this gene have been linked to progressive myoclonus epilepsy. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 3.

Pathway

Wnt signaling pathway, organism-specific biosystem; Wnt signaling pathway, conserved biosystem;