Anti-PRDX3 (full length) polyclonal antibody

Species Reactivity

Human

Immunogen

PRDX3 (AAH02685, 1 a.a. ~ 256 a.a) full-length recombinant protein with GST tag. The sequence is MAAAVGRLLRASVARHVSAIPWGISATAALRPAACGRTSLTNLLCSGSSQAKLFSTSSSC HAPAVTQHAPYFKGTAVVNGEFKDLSLDDFKGKYLVLFFYPLDFTFVCPTEIVAFSDKAN EFHDVNCEVVAVSVDSHFSHLAWINTPRKNGGLGHMNIALLSDLTKQISRDYGVLLEGSG LALRGLFIIDPNGVIKHLSVNDLPVGRSVEETLRLVKAFQYVETHGEVCPANWTPDSPTI KPSPAASKEYFQKVNQ

Conjugate

Alternative Names

PRDX3; peroxiredoxin 3; AOP1; MER5; AOP-1; SP-22; HBC189; PRO1748; prx-III; thioredoxin-dependent peroxide reductase, mitochondrial; peroxiredoxin-3; peroxiredoxin III; protein MER5 homolog; antioxidant protein 1;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a protein with antioxidant function and is localized in the mitochondrion. This gene shows significant nucleotide sequence similarity to the gene coding for the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase. Expression of this gene product in E. coli deficient in the C22-subunit gene rescued resistance of the bacteria to alkylhydroperoxide. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologues suggest that these genes consist of a family that is responsible for regulation of cellular proliferation, differentiation, and antioxidant functions. Two transcript variants encoding two different isoforms have been found for this gene.

Pathway

Cellular responses to stress; Selenium Pathway;