Recombinant fragment corresponding to Human PPP1R16B aa 45-264. (BC131801).Sequence: QHRKRKHERKRSTGGRRKKVSFEASVALLEASLRNDAEEVRYFLKNKVSP DLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATC GHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGITQ EKINEMRVAPEQQMIAD
Conjugate
Unconjugated
Applications
Application Notes
IHC-P: 1/100 - 1/500; WB: 1/200 - 1/1000.
Target
Alternative Names
PPP1R16B; protein phosphatase 1, regulatory subunit 16B; protein phosphatase 1, regulatory (inhibitor) subunit 16B; protein phosphatase 1 regulatory inhibitor subunit 16B; ANKRD4; ankyrin repeat domain protein 4; KIAA0823; TGF beta inhibited membrane asso
Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function. Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation. Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1. Involved in the regulation of endothelial cell filopodia extension. May be a downstream target for TGF-beta1 signaling cascade in endothelial cells.
Citations
Publication ()
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