Anti-PPARGC1B (aa 914-1023) polyclonal antibody

Species Reactivity

Human

Immunogen

PPARGC1B (NP_573570, 914 a.a. ~ 1023 a.a) partial recombinant protein with GST tag. The sequence is SSRELKRRFEVFGEIEECEVLTRNRRGEKYGFITYRCSEHAALSLTKGAALRKRNEPSFQ LSYGGLRHFCWPRYTDYDSNSEEALPASGKSKYEAMDFDSLLKEAQQSLH

Conjugate

Alternative Names

PPARGC1B; peroxisome proliferator-activated receptor gamma, coactivator 1 beta; PERC; ERRL1; PGC1B; PGC-1(beta); peroxisome proliferator-activated receptor gamma coactivator 1-beta; PPARGC-1-beta; PPAR-gamma coactivator 1-beta; PGC-1-related estrogen rece

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene stimulates the activity of several transcription factors and nuclear receptors, including estrogen receptor alpha, nuclear respiratory factor 1, and glucocorticoid receptor. The encoded protein may be involved in fat oxidation, non-oxidative glucose metabolism, and the regulation of energy expenditure. This protein is downregulated in prediabetic and type 2 diabetes mellitus patients. Certain allelic variations in this gene increase the risk of the development of obesity. Three transcript variants encoding different isoforms have been found for this gene.

Pathway

AMPK signaling; Fatty acid, triacylglycerol, and ketone body metabolism; Metabolism of lipids and lipoproteins; Mitochondrial biogenesis