Anti-PPARGC1B monoclonal antibody, clone FQS23481

Antibody Isotype

IgG

Clone

FQS23481

Species Reactivity

Mouse; Rat; Human

Immunogen

Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human PGC1 beta aa 950 to the C-terminus (Cysteine residue). The exact sequence is proprietary.Database link: Q86YN6

Conjugate

Application Notes

WB: 1/1000 - 1/10000; ICC/IF: 1/100 - 1/250; Flow Cyt: 1/10 - 1/100; IP: 1/10 - 1/100.

Alternative Names

PPARGC1B; peroxisome proliferator-activated receptor gamma, coactivator 1 beta; peroxisome proliferative activated receptor, gamma, coactivator 1, beta; peroxisome proliferator-activated receptor gamma coactivator 1-beta; PERC; PGC1B; PPARGC-1-beta; PPAR-

Entrez Gene ID

UniProt ID

Antigen Description

Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcritional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure.

Pathway

Energy Metabolism, organism-specific biosystem; Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of lipids and lipoproteins, organism-specific biosystem; Mitochondrial Gene Expression, organism-specific biosystem; PPARA Activates Gene Expression, organism-specific biosystem; Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystem.