Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents.
Pathway
Metabolic pathways;
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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Reddy, ST; Wadleigh, DJ; et al. Human paraoxonase-3 is an HDL-associated enzyme with biological activity similar to paraoxonase-1 protein but is not regulated by oxidized lipids. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 21:542-547(2001).
Aragones, G; Guardiola, M; et al. Measurement of serum PON-3 concentration: method evaluation, reference values, and influence of genotypes in a population-based study. JOURNAL OF LIPID RESEARCH 52:1055-1061(2011).
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