Anti-POLR3F monoclonal antibody, clone FQS24311

Antibody Isotype

IgG

Clone

FQS24311

Species Reactivity

Mouse; Rat; Human

Immunogen

Recombinant fragment within Human POLR3F aa 1-200. The exact sequence is proprietary.Database link: Q9H1D9

Conjugate

Application Notes

WB: 1/1000 - 1/10000.

Alternative Names

POLR3F; polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa; polymerase (RNA) III (DNA directed) polypeptide F (39 kDa); DNA-directed RNA polymerase III subunit RPC6; RNA polymerase III C39 subunit; RPC6; RPC39; RNA polymerase III subunit C6; RNA po

Entrez Gene ID

UniProt ID

Antigen Description

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct RNA Pol III binding to the TFIIIB-DNA complex. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.

Pathway

Cytosolic DNA-sensing pathway, organism-specific biosystem; Cytosolic DNA-sensing pathway, conserved biosystem; Epstein-Barr virus infection, organism-specific biosystem; Epstein-Barr virus infection, conserved biosystem; Gene Expression, organism-specific biosystem; Metabolic pathways, organism-specific biosystem; Purine metabolism, organism-specific biosystem;