POLB (AAI06910.1, 224 a.a. ~ 333 a.a) partial recombinant protein with GST tag. The sequence is ITDTLSKGETKFMGVCQLPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMR AHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDR
Conjugate
Unconjugated
Target
Alternative Names
POLB; polymerase (DNA directed), beta; DNA polymerase beta; DNA pol beta; mutant DNA polymerase beta; DNA polymerase beta subunit;
The protein encoded by this gene is a DNA polymerase involved in base excision and repair, also called gap-filling DNA synthesis. The encoded protein, acting as a monomer, is normally found in the cytoplasm, but it translocates to the nucleus upon DNA damage. Several transcript variants of this gene exist, but the full-length nature of only one has been described to date.
Pathway
BER complex; Base Excision Repair; Base excision repair; DNA Repair
Citations
Publication ()
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