Synthetic peptide corresponding to a region within N terminal amino acids 2-51 (AVTAQAARRK ERVLCLFDVD GTLTPARQKI DPEVAAFLQK LRSRVQIGVV) of Human PMM1 (NP_002667).
Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. In addition, may be responsible for the degradation of glucose-1,6-bisphosphate in ischemic brain.
Pathway
Amino sugar and nucleotide sugar metabolism; Asparagine N-linked glycosylation; Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein; Fructose and mannose metabolism; GDP-mannose biosynthesi
Citations
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