General Notes
This product (Catalog No. DPABH-04266) is a rabbit-derived polyclonal antibody raised against human PLRG1. This antibody exhibits cross-reactivity with PLRG1 from mouse and rat. It has been affinity purified by Protein A. PLRG1, officially known as pleiotropic regulator 1, is a protein-coding gene located on chromosome 4q31.3 in humans that encodes a core component of the spliceosome, a molecular machine essential for pre-mRNA splicing and alternative splice site selection. This evolutionarily conserved protein, characterized by multiple C-terminal WD40 repeats, forms part of the CDC5L complex (also involving PRPF19 and CDC5L) and contributes to both RNA processing and DNA repair mechanisms. Expressed ubiquitously across tissues with highest levels in the thyroid and brain, PLRG1 plays a critical role in regulating p53-dependent cell cycle progression and apoptosis, making it indispensable for cell proliferation and embryonic development. Disruption of PLRG1, as demonstrated in mouse and zebrafish models, leads to early embryonic lethality due to failed cell division, activation of DNA damage responses, and widespread apoptosis.
DPABH-04266 is suitable for use in ELISA 1 (20000-1:40000) application.
DPABH-04266 is supplied as a liquid formulation in Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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