Specifications
Species Reactivity
Human; Mouse
Immunogen
A synthetic peptide corresponding to amino acids at internal region of human PLA2G4A. The sequence is C-QEKTFRQQRKEHIR
Applications
Application Notes
ELISA: 1:32000; WB: 1-3 μg/mL. & The optimal working dilution should be determined by the end user.
Target
Alternative Names
PLA2G4A; phospholipase A2, group IVA (cytosolic, calcium-dependent); PLA2G4; cPLA2-alpha; cytosolic phospholipase A2; cPLA2; lysophospholipase; phospholipase A2 group IVA; phosphatidylcholine 2-acylhydrolase; calcium-dependent phospholipid-binding protein
Product Background
Antigen Description
This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.
Pathway
ADP signalling through P2Y purinoceptor 1; Acyl chain remodeling of CL; Acyl chain remodelling of PE; Acyl chain remodelling of PI
Citations
Publication ()
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COA
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