Anti-PLA2G4A (aa 1-110) polyclonal antibody

Species Reactivity

Human

Immunogen

PLA2G4A (NP_077734, 1 a.a. ~ 110 a.a) partial recombinant protein with GST tag. The sequence is MSFIDPYQHIIVEHQYSHKFTVVVLRATKVTKGAFGDMLDTPDPYVELFISTTPDSRKRT RHFNNDINPVWNETFEFILDPNQENVLEITLMDANYVMDETLGTATFTVS

Conjugate

Alternative Names

PLA2G4A; phospholipase A2, group IVA (cytosolic, calcium-dependent); PLA2G4; cPLA2-alpha; cytosolic phospholipase A2; cPLA2; lysophospholipase; phospholipase A2 group IVA; phosphatidylcholine 2-acylhydrolase; calcium-dependent phospholipid-binding protein

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.

Pathway

ADP signalling through P2Y purinoceptor 1; Acyl chain remodeling of CL; Acyl chain remodelling of PE; Acyl chain remodelling of PI