This product (Catalog No. DPABH-22392) is a rabbit-derived polyclonal antibody raised against human PLA2G1B. This antibody exhibits cross-reactivity with PLA2G1B from mouse and rat. It has been affinity purified by Protein A. This gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic enzymes to several bioactive lipophilic compounds (eicosanoids), including prostaglandins (PGs) and leukotrienes (LTs). The enzyme may be involved in several physiological processes including cell contraction, cell proliferation and pathological response. DPABH-22392 is suitable for use in Western blot (WB) (1:1,000–1:3,000) application. DPABH-22392 is supplied as a liquid formulation in PBS containing 50% glycerol, and 0.02% sodium azide. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
Target
Alternative Names
PLA2G1B, Group IB phospholipase A2, Phospholipase A2, PLA2A, PPLA2, PLA2
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